G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation
نویسندگان
چکیده
منابع مشابه
mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1.
The glycine-alanine repeat (GAr) sequence of the Epstein-Barr virus-encoded EBNA-1 prevents presentation of antigenic peptides to major histocompatibility complex class I molecules. This has been attributed to its capacity to suppress mRNA translation in cis. However, the underlying mechanism of this function remains largely unknown. Here, we have further investigated the effect of the GAr as a...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2014
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1479